The octagon of doom refers to the act of having unprotected sex with a prostitute in a 3rd world country without a condom. Hence, the octagon is formed by the 8 diseases one is likely to contract, AIDS, Chlamydia, Gonorrhea, Syphilis, Crabs, HPV, Scabies, and Herpes.
"you were really taking your chances with the octagon of doom when you visited that whorehouse is Rwanda"
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