Defined by Audrey Hepburn's character, Holly Golightly, in the movie "Breakfast at Tiffany's" as the opposite of "A case of the blues". Instead of becoming sad, "a case of the reds" infers that one is feeling overwhelmed or angry for no apparent reason.
When I heard that I would have to speak in front of a large audience, I suddenly got a case of the reds.
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