1. Your ex best friend who fucked up your high school life and is now fucking your ex.
2. Peter Pettigrew, because why the fuck not, he was a real bitch.
3. Your best friend who'll never ditch you for a date with her man.
1. "Oh, yeah, she's fucking with my toy now, I thought it was broken but idk tho."
2. "Peter Pettigrew is a bitch from Harry Potter who betrayed the best friend who never suspected him."
3. "You mah bitch."
Basically bitch is used for friends, real and fake, both.