1. The moment when a mind-altering substance begins to act in one's system.
2. The onset of the effect(s) of a mind-altering substance after its inhalation, ingestion or injection.
Dude, you'll definitely take-off before you finish smoking that giant blunt.
Typically used on the east coast from Georgia down to Ohio. Taking off essentially means that you have just taken several hits of a joint. Take off is the act of getting stoned.
Person 1: “hey bro do you wanna take off right now?”
Person 2: “let’s do it man, let me grind these bud and roll it bro!”
Taking a piss off the Hollywood sign either is protesting the perfection wanted of people or physically urinating off said sign.
Man:”I went and got a drink.”
Man 2: “Oh no.”
Man: “Yeah I ended up Taking a piss off the Hollywood sign.”
Man 2: “Protesting?”
Man: “No... literally.”
The act of leaning far forward whilst sitting on the toilet to help ease out a particularly difficult/large stool
“Mate that was terrible, I’m all backed up, it was so bad I was leaning forward like a goose taking off trying to squeeze that one out”
Fuck her so hard that her makeup comes off.
Yeah, she wanted me to take her makeup off.
Take the hood off the hawk: the act of pulling back the foreskin to expose the glans of the penis.
"When I'm lathering myself in the shower, I make sure to take the hood off the hawk—it's the final touch for a job well done!"