Alternative: "I don't know"
In conversation, when the person speaking to you wants you to feel like you're part of the conversation, but doesn't want to give you an opening. This conveniently allows the speaker to continue to ramble on about something trivial while the other person can only stand there and take it.
I'm not sure what your favorite movie is, but mine is Garden State, and this is why...
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Sure, (Sorry Ass Nigga)....
A nothing, worthless man not worth your time.
John: Baby i promise i would never cheat on you, i love you.
Lisa: Sure SAN
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Having great confidence in your heterosexuality while being in stereotypical homosexual situations
responding after getting picked on by my buddies at the bar for going to a Jewel Concert in a pink button-up shirt: "you're just jealous you are not as Hetero-sure as I am!"
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When you ask someone a question you already know the answer to.
Dumbo: You're off work on Thursday right?
You: Umm, yeah... last week we made camping plans on that day since I'm free, remember?
Then you said "oh right, you're always off on Thursdays"
Dumbo: Sorry just had to "firm-a-sure"
When you're sure but don't know for a fact
I'm 99% sure that's not what he meant