knuckle-up

An action akin to the high-five or the handshake. The act of touching fists knukle-to-knuckle in greeting or departure. In 2003 this action was accompanied by the phrase "knuckle-up" but has since just become the motion without the phrase. The first instance of this action and phrase was in Dallas, TX in the mid-90's and has since become a common gesture in most public forms of transit in NYC.

Jimbo-- "Is that some kind of a gang sign?"
Miguel--"Nah, that's a knuckle-up, bro."

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knuckled up

To get belligerently drunk, to the point of blacking out and making choices you may regret

Anyone want to go get knuckled up at Applebee’s with me?

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Knuckle up

To masturbate
The act of masturbation

Guy 1: Did you see Stacey?

Guy 2: Yeah, total nipple slip! I'm totally going to knuckle up to that later

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Knuckle Up

When two men choose to engage in mutual masturbation, implementing a "thumb war" grip and jerking themselves off simultaneously, locked at the knuckles.

Since he had a girlfriend, the young man decided to knuckle up with a buddy.