Comparable to the phrase "rain on your parade"; something that brings you down and/or sucks in a major way.
Sally, you look so sad. I wonder who shit on your Skittles?
You know, I was having a great day... don't come over here and shit on my Skittles, butthole.
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When you poop out like 1000 little turds in one push.
Jeeese that tako bell really gave me Skittle Shits
The act of having colored shit
Honey after I ate those cookies I got a shit skittle
The act of shoving skittles up a mans ass a shitting it out on his/her face
Jen really fucked me up with that shit skittle