what the deuce

A generalized inquiry as to the nature or overall well-being of someone or something.

What the deuce are my keys doing in the toilet, again?

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WHAT THA DEUCE!

Appropriate response when an act, event, opinion, or statement is stupid, and/or ridiculous, doesn't make sense or is just plain fucked up.

KITTY: Hey Red, guess what I'm getting my husband for our anniversary?....I'm having laser hair removal!!

RED: WHAT THA DEUCE!

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What the deuce?

An expression made by the most iconic gay cartoon character.

Stewie Griffin. Stewie Griffin uses the expression "what the deuce?"