mano e mano

man to man, one on one, usually used in the context of a physical confrontation / altercation between two gentlemen.

okay, buddy, you and me, mano e mano.

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mano y mano

"mano y mano" is Spanish for Hand to hand. Usually associated in engaging in throwing fisticuffs with two or more people, usually two.

Is layman's terms, a fight, but not usually followed closely to it's meaning. Often times, swords, or other weapons, not involved with guns or firearms, are associated with the term.

All right, Robin. Let's go at it. a fight to the death, you and me, Mano y mano, just you and me and my GUARDS!

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mano 'o' mano

when you go full warfare one on one man on man (don't think about) battle to the death

dude 1: minecraft is trash
dude 2: nah fam
the creepy world narrator: there going mano 'o' mano