A word often used nowadays to insult a friend, previously meaning women's genitalia.
Wow, Marisa you're such a twat!
a twat is someone who tells the whole world he is a best seller when he has only sold about 30 books
Richard James Rogers is a twat.
derogatory acronym for a group of stupid females: These Women Aren't Thinkers
"Hey did you see Star Jones & Whoopi Goldberg on the View this week?"
"Yeah... talk about TWAT"