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When two men touch their buttholes together.
Wow-wee Johnny sure gave me a great San Francisco Kiss last night!
A gay couple, though not necessarily located in San Francisco.
No, we are not in fact San Francisco roommates.
A National League baseball team with the best pitching staff in the MLB and the worst hitting in the MLB.
John: Fuckin' a, the San Francisco Giants hitting is once again terrible this year.
Mike: You know, they say defense wins ballgames. With Barry Zito, Tim Lincecum, Matt Cain, and Jonathan Sanchez, their pitching will be phenomenal this year.
John: Yeah, too bad they haven't scored a run to back that up since the Nixon Administration.
A two-pair poker hand in which two queens or two kings are present. San Francisco is often generalized as having many homosexual individuals and being on the forefront of gay marriage; thus, having two queens, or "women", or two kings, or "men", creates a gay "wedding/marriage" and a San Francisco Wedding.
Joe, Sarah, Bob, and Anna are playing poker.
Joe: "I'll see your $20 and raise you $50"
Sarah: "I call. I've got a San Francisco Wedding."
Bob: "What's a San Francisco Wedding?"
Anna: "A two-pair with queens or kings, Bob. I've got a full house, though. PWN!"
An act that involves a gay man sticking a dollar-store calculator into another man's anus.
Abe: I was shitting pancakes after you gave me that San Francisco Calculator, Blake.
Blake: If you don't stop complaining, I'll have to use a TI-83 next time.
When a gay man punches a woman in the face.
She was giving Mario lip, so he gave her the San Francisco Shiner.