screwing the pooch

The definition comes from when you go to your car and the driver unlocks the doors but you pull the handle to soon. What happens from this is your door remains locked but every other door in the car is unlocked. People refer to this as screwing the pooch.

Narrator: Person one and person two are outside of their car as person one unlocks the car doors. Person two accidentily opens the car door too soon making his door stay locked.
Person one: Dude, why you be screwing the pooch!
person two: ya well...ur mom!!!

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screwed the pooch and knocked it up

To have made a massive, catastrophic blunder. An extension of the more common "screwed the pooch," which adds a more severe consequence to the metaphorical action.

Since invading Iraq, President Bush and his advisors have really screwed the pooch and knocked it up.

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Screwed The Pooch

You've fucked up so bad the only real way of describing it is as though you have fucked a dog and have to explain it to your parents.

Morty: awe geez I really screwed the pooch on that one.

Rick: nice going morty, snowball will definitely neuter you after that stunt.