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Old US slang from the 1920s/30s meaning to 'Beat it' 'Scram' 'Move it' 'Get Going' etc. 'Taking a powder' was a commonplace phrase pre-WW2 particularly in the medical field where a doctor would instruct his patient "to take a powder" post assessment.
In American usage, the "powder room" is a euphemism for the ladies lavatory, and the phrase "to powder one's nose" indicates the immediate exit of a lady toward this room. Thus, to "take a powder" is to leave, rather quickly, but with discretion, and without further comment. It appeared in movie and gangster novel lingo in the 1920's.
EXAMPLES:
1) In 1941 song "Let's get away from it all" , Frank Sinatra w/ Tommy Dorsey Sings "....Let's take a powder to Boston for chowder" (ie lets vanish away for a vacation to Boston to eat some chowder)
2) George Raft in the 1939 Film Each Dawn I Die instructs he gangster colleagues to powder after their meeting.
Chad be takin some of that brotein powder, getting all jacked and swole
Powderful - Power + Wonderful. A slang that was derived from a deliberate mispronunciation of powerful.
Powderful is often used as a pun to sarcastically praise someone of his/her qualities.
Ah Seng: “Ah Beng, your english is sibeh powderful. I witnessed your conversation with the ang moh when you were trying to sell her perfume. You used phrases like “a person of your elegance and class” lah, “befitting your simi status“.
A really awesome powder version of codeine that people have to rob pharmacies to get.
He just got dome powder from the guy upstairs.
The flavored and often colorful powders which season much junk food. Flavor powder is most obvious once it has been transferred from snack to fingers, as is most vividly illustrated by Cheetos.
Why are you eating those chips with chopsticks?
So I can keep gaming without getting flavor powder all over my keyboard, you amateur.
Girls that use/wear excessive makeup
omg that girl is such a powdered donuts
do you like powdered donuts? no bruh!
When one person simultaneously leans over and spreads their cheeks, while the other blows Colombian Bam Bam into their B hole.
Bro, last night was crazy. Eric and I gave each other Powdered Donuts, we were poppin off.