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A person (preferably a male) who only has one testicle due to circumstances like cancer, etc.
I heard Sam had cancer and became a one nut.
To like sb's comment on a social networking site such as Facebook.
"People constantly seek attention and validation through one-upping people's comments"
One up from the least desirable bag of weed to buy
It's one up bro said the Waihekean to his stoner mate meaning the bag of weed is shit
When your massive dong goes from a heads down to a heads up position, you gotta let that honey pie know you just got a one up.
Check to see if she wants that mushroom power-up
Damn horbino, yo cleavage just gave me a one up. Grab a wheelbarrow and help me transport this mushroom load to bitches in need of a mushroom tip infusion.
The phrase 'real ones only' is most commonly used in a Snapchat 'smo' and is another way of saying only loyal tings
*+++ the stunner up real ones only*
Someone who knows so little about computers that more than one button will confuse them.
"The users computer had eight buttons. After I guided this person through pushing all buttons over the phone to no effect. It turned out that the computer wasn't plugged in. Clearly she's a One Button User."