To express dissatisfaction towards the prefix. Another term for saying you suck.
Ex. Bob2lose- Bob sux, i hope bob dies, bob is a douche.
Ugly people2lose
Poop2lose
Saddam2lose
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The oppostie of 2win. See 2win
(bob and joe are fighting) Joe2lose
Cheese suxxorz...cheese2lose
flat tits2lose