Mental and Physical breakdown following the failure to win a much-hyped reality talent show.
eg. Susan Boyle on 'Britain's got Talent.
Andy: Did you see that Big Brother has-been freakout in Wallmart yesterday?
Tom: Yeah ... Boyle's Syndrome again .. he'll be in a psych ward come Christmas.
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When one over uses funny jokes to such an extent that the jokes themselves become unfunny. As seen in the "comedian" Frankie Boyle.
You've over-used that joke so much! You got Frankie Boyle Syndrome?
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