The feeling of sadness Notre Dame students feel when away from campus. It's a pun on homesick based on the Golden Dome on ND's main building.
After I graduated, I was so domesick.
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experiencing a longing for receiving oral sex during a period of absence from it, a la "homesick"
I hate that I moved 1000 miles away from my girlfriend. I feel so domesick.
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Feeling or showing nostalgia for sporting events in the Carrier Dome, home of the Syracuse Orange, most often affecting Syracuse graduates and washed-up former college athletes and play-by-play announcers.
I'm so Domesick, all I want right now is a Dome Dog and a selfie with Otto.