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The act of going to the guadalupe river, renting toobs, drinking lots of beer, and hooking up with the opposite sex.
Matthew McConaughey: Hey man what are you doing this weekend?
Lance Armstrong: Dude, I'm headin to New Braunfels to get guadalupified.
Matthew McConaughey: Right on, Right on.
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The condition of having had sex with a dirty Mexican.
After Playing Yu-gi-oh, Ashley was severely Guadalupified.
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