When the act of getting harassed is causing a hassle. For example, somebody making you do something that is really out of the way and they insist that it is done now when you really don't want to. It can be summed up by pretty much anything your parents ask you to do.
Man, house-sitting my parents dogs this week is going to be such a harassle.
That's all the way over town! What a harassle.
the act of simultaneously harassing and hassling; to persistently irritate and inconvenience
I can scarcely get my work done with everyone hovering and harassling me all day.
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When you harass and hassle while being an asshole
"You've harassled me 3 times about that money I owe you in 2 hours and I paid for lunch!