This is a term exclusive to Mayar Malik. "Man-Khoola" or "Mankhoola" is the act of Mayar Malik having a temper tantrum and/or acting like a little angry boy.
Mayar Mailk: Yousef can we hangout tomorrow?
Yousef: No, sorry I can't. I am volunteering.
Mayar Malik: *makes sounds with her nose* NOOOOOOOOO ;((((((((((
Yousef: Stop acting like a Man-Khoola!