Means sister in Japanese often people who watch the popular Anime Re:Zero will use it.
Rem: Nee-sama Nee-sama, could our guest be a troubled man, deriving pleasure from torture?
Ram: Rem, Rem our guest appears to be a pervert who's turned on by our insults.
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Means "sister" in Japanese, mostly used by rem from Re:zero
Rem: "nee-sama ,nee-sama"
Ram: "rem ,rem"
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