You can be infected with Squatters Knob through contact with shady or moist people from places such as Ipswich or Narara. The cause of Squatters Knob is an enigma to the medical community due to its rapid spreading nature a no known cure.
Jamie was lurking in the shadows of the Ipswich tavern smoking area, when suddenly Friendy's mother cornered him with pulsating intention and infected him with Squatters Knob.