While "beeho" is best left undefined for ease of use and entertainment purposes, a common definition is "bitch-ho."
The word was originally defined in reference to a dog's butthole. It has since been adopted by many young people and has become a beloved, nonsensical word to be used whenever deemed appropriate.
Rachel is such a beeho. I can't believe she cancelled our plans to ride the mechanical bull.
Oh, you know Ellie's gettin' it. Lookit that beeho.
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