When you either try to attempted or manage to colonize or destroy the galaxy. In the universe there's at least two galaxies maybe three. The goal of a galacticide is to kill one entirely all 9 planets in the galaxy that's been victim to glacticide..
Can be done by mixing chemicals with your food such as trinitite or uranium types with a casing and detonator.
Can also be done by dropping your Marijuana into your bowl of meth and smoking it out of a vacuum cleaner.
A glacticide means the whole dimension dies or falls victim to something.