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Random
Chet: That girl looks awfully masculine
John: Haha Chet, that isn't a girl, that's a mister sister
Chet: A what?
John: A mister sister. A shemale. A tranny. You gettin' it?
A drag queen.
Origin: "Will and Grace"
Don't mess with that mister sister, or you'll end up looking like a Cher barbie doll gone bad.
Someone of the male species, that wants and or appears to look like a female.A male that is very feminine, also known as a "shemale"
That gay guy looks like mister sister
The most destructive comeback to date. Only to be used in very dire situations. (Can be used if target doesn't have a sister)
Joe: ur mom gay
Tim: no u
Joe: UR DAD LESBIAN
Tim: UR GRANNY TRANNY
Joe: UR PAPPY TRAPPY
Tim: UR SISTER MISTER
*At this point time ceases to exist. The very fabric of the universe has be torn to shreds, the entire 3rd dimension is incinerated and all life on earth ceases to exist*
An insult that has the same effect as your mom gay.
Friend 1: Your Mum Gay
Friend 2: Your Sister Mister
Friend 1: *Dies From the Insult*
The worst possible insult ever in the entire world apart from your granny tranny
"Your Granny Tranny lol!"
"Ha! Your sister mister"
*implodes*
A white man who exclusively dates and is attracted to black women. He usually dresses and acts black or uneducated. The male version of a queen of spades or bro hoe.
Chad won't date Jessica because he's trying to get with Sharifa, he's such a sister mister.