Someone who is a bit confused or slow minded. Used in a context of endearment most of the time.
"Where are my glasses?"
"You're wearing them, noodle brain!"
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when someone is sooo dumb that there brain doesnt function properly, has a very bad memory that their brain is literally a bunch of noodles. (very mushy noodles
Alyssa: Omg i took a wiz in the bush over there...hold up wheres my dog
Amber: Alyssa your wiz stinks
Charlotte: Omg you forgot your dog you've been walking a leash
Both: your such a noodle-brain
Alyssa: duhhhhh
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A completely brain dead imbecile.
That dude is a real Noodle brained muppet.