To use crystal meth. The term comes from "sixteenth" as in a sixteenth of an ounce. Often used when non-users are around and one doesn't want them to know what is being discussed.
<you're in mixed company so you say:>
"Um... Joey, you wanna party with Tina tomorrow night?"
<he replies:>
"Sure, dude."
<and then you change the subject>
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