To fist a girl's vagina or ass or a Man's ass so hard and fast that either time explodes or the universe comes apart at the seams. Enducing lulz.
Powerfisting must be used in conjuction with the "powerfist shout" in order to reach maximum power and lulz.
Wendy: Yeah, don't stop...more
Gary: How about a powerfisting?
Wendy, Yeah..do it..
Gary POOOOOOOWERFIIIIIIIIIIST!
*Universe collapses*
When you give a guy a deep anal fisting.
Guy 1: Bro I gave Chad a powerfist the other day
Guy 2: Damn, can you try me now