when someone is used sexually by consecutive people.
last night be and my boys ran a train on that chick
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ey homie last week me n ray ray ran a train on dat bitch keyashia he fuckd her n da back n i fucked he n da front it was da shit!!
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When there's 2 guys fucking a girl; one, "the conductor", fucking her mouth, the "middle cart" the girl getting fucked, and "the caboose", the guy fucking her from behind in the puss or ass
Matt and Jason ran a train on lizzie when her bf was out of town
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Relating to eating food, When you eat a particularly large amount of food due to a huge hunger.
Man, I was so hungry yesterday. I ran a train on those tacos.
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When a girl or boy or a hoe has sex with a lot of guys in a short amount of time
Guy: yooo did you hear ... got ran over by a train
Other guy: yeah she is a hoe, imma tap that next cause I need a booty call
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