The intense rushing sensation that occurs from a large injection of methamphetamine. Depending on how potent, if male, your dick could start to get hard. If exceptionally strong you may, even as a straight man, desire to have you anal cavity stretched past reasonable limits.
Straight guy:
The slam-rush I get from this sack of dope makes my heart race, and makes me want a whole fist up my ass.
Gay bro: I know what you mean. Now ram that cock down my throat after I get my slam-rush.