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When you take a fifth (or any alcoholic beverage) and pull er in the out chute to get the goods straight to the main vein. AKA: Butt chuggin
Barry: Hey man, Jim is fucked up and he just got to the party!
Mike: Yea.. as soon as he got here he gurgled up a spicy enema! He's wasted!
When you squeeze diet coke up your ass to cleanse yourself.
"You're okay to fuck me with the strap-on babe, I've had a spicy enema."