When someone has to hand a grown man a tissue for his mommy issues because he is acting like a little bitch.
Example: Someone could say “Do you need a tissue for your missue” or missues if it is pleural or there are multiple mommy issues one is crying over.
Frank do you need a “tissue for your missue” because you are complaining about your wife again!
Sarah asked David “Do you need a tissue for your missue, David?” because he is crying about his gf Beth again; Something about his dinner being cold...