A reference to the absolute banger 1Thot 2 Thot Red Thot Blue Thot by Yung Gravy. Not quite as good as a one thot.
McCasual is honestly such a two thot.
The feminine version of the 2 beer queer
That ho is such a two-shot thot. I mean, her standards are already pretty low, but get a couple shots in her and she'll start hitting on people as ugly as she is!