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A cry of despair. Acronym slang for "why oh why oh why?".
Man, yoyoy did the kid have to upchuck on my interview suit?
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It's a plain statement. It's particularly used when someone does something weird.
Your friend: I managed to do poo-poo while standing up
You: yoyoy.
A hidden way of saying you enjoy the act of pegging a yo-yo collector
Lucy: "Okay yoyoi."
Everyone else, collectively: "Shut up."