Abbreviation for 'You Sick Fuck'.
I can't believe you dipped your balls in the pizza dough, ysf.
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You Stupid F***.
Michael, YSF, you miss the whole point.
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short for "You're So Funny"
lol that was a good joke! YSF!
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YSFS means "You So Fuckin(g) Stupid"
Can be used as a way to get out of a conversation that you may not want any more part in, or can be used as a plain flat out roast, or someone who is generally just flat out dumb.
1. I swear to god bro, ysfs
2. I can't stand you anymore! YSFS
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