P.O stands for Project Originalz, a hood in Toronto, Ontario. The P.O is affiliated with the Piru Bloods gang. The P.O is sometimes called "Alexandra Park".
1: Yo nigga whats poppin' in the P.O
2: Nothin' much, just another day another dead man
P.O means Piss off or pissed off.
O M G! She like stole my whole bag of chips and I got so P.O. "P.O!! Give them back!"
P.O stands for "Projects", P.O also is slang for "Alexendra park" inner city in toronto
"yo those p.o niggas got gats"
A term used to describe a smelly vagina.
Mac:Dude I heard Jackie was finally about to give you some but you turned it down! What happened?!
Jason:Man she had P.O like crazy! I was mad disappointed
Mac:Aw man that sucks bro..