As popularized by both ASAP Ferg and Three Six Mafia SANDOS is an abbreviation of arguably the best part of Plain Jane and Slob on My Knob: "Suck A Nigga Dick Or Something" or "Suck A Neighbor/N***a Dick Or Something" (if you're not black).
Friend 1: Hey bruh, did you see that guy flying.
Friend 2: Nah stfu, SANDOS bruh
L33t way to say....Suck a Nigga Dick Or Something
Hey you sure do got a purdy mouth. Ever SANDOS?
SANDOS simply means Suck A Nigga Dick Or Something. It originated from plain Jane remix
Alice: Yo bitch, why you staring at me?! You wanna fight?
DD: Bitch ain't no one got your time. SANDOS
Students Against Narcotics and Destructive Oriented Situations
Last week I went to a SANDOS meeting.