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When a person is doing childish shit, acting immature, or being petty. Usually used in the negative sense like the previous examples, but it can also be used when you're currently messing around for no reason and just killing time.
Quit twerping around with that Dance game already and let's get the hell out of here!
runt sized pest, generally annoying little person
Can you believe that twerp is complaining again!
A younger kid that is an annoying pest.
That twerp just stole my sandwich!
Ash Ketchum and any of his friends, according to Jessie, James, and Meowth.
Jessie: Oh no, it's the twerps! Time to get that Pikachu...
annoying "twerp" with a high pitch squel in your ear when you wake up in the morning feeling digusted to hear a pre-pubed boy singin and prancin like a balet and fat viking singin chick type combined.
A person that farts in the bathtub then bites the bubbles.
Look at that Twerp. He's one nasty mother fucker.