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To become accustomed to something to the point of desensitization.
Man! I’ve had so many of these chocolates that I’ve become substitized to the taste of them!
The oppisite of a superstition, a substition is the belief in something that is utterly true. Coined by Terry Pratchett in 'Making Money'.
When my mother told me not to pick at my scab or it wouldn't heal, I saw immediately that she was very substicious (believing greatly in a substition).