1. A girl who is looked at as a hoe or slut that also is large in size due to unhealthy eating habits and lack of exercise
2. A promiscuous hippo
1. âMan she gave great head, but sheâs a bit of a thotopotamusâ
2.âWhatâs the weirdest thing youâve stuck your dick in?â Said Cotton eyed joe to Alfonzo. âDamn bro, you ever seen the ass on a thotopotamus?â