A female person (or, conceivably, a female alien or a gorilla or something) who, literally or figuratively, throws (something or someone) from a window.
Loan word from the Italian (non-proper) word "defenestrata; " see en.wiktionary.org/wiki/defenestrata. The English word "defenestrate" means "To eject or throw (someone or something) from a window" (en.wiktionary.org/wiki/defenestrate). The natural feminine word for one who defenestrates would be "defenestrata."
Used literally: "Yeah, after Pat got fired, she threw everything in and on her desk out of the window. She's quite a defenestrata."
Used figuratively: "Yeah, after all of the people the CIO fired, she's quite a defenestrata."