1)To make an accidental innuendo without realising it in general conversation.
2)To fall over in a hilarious manner.
1)Katie: Then we should shoot all the blondes!
Louise: Can I keep them all afterwards? I love blondes.
Katie:....Necrophiliac!
Louise: I didn't mean it like that it was a total Lu-ism
2)Penny: Did you see Janie just fall of that seat over there, it was hilarious. Best lu-ism from her YET!