A drunken womanizer/manizer (yes, they exist).
Tyrion Lannister is a bit a lush, but we don't hold that against him.
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When you see something so excessive, amazing, horrifying, fortuitous, or otherwise awesome, that you are bereft of any other words to say.
Scott: "That guy just walked out the flaming wreckage after a car accident!"
Bob: "Holy fuck knuckles! He is still walking!"
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A term reserved for a bastard child that is angry about being a bastard.
"It's not my fault your parents were whores, you fucking clit pimple."