don't lose skin

Similar to 'no skin off my nose'

I don't think they like your idea but don't lose skin over it.

Lose my pills

To be angry or upset

If my kid gets out of bed one more time, I’m going to lose my pills.

Lose a shit

The act of shitting yourself in a fit of extreme excitement or shock. Popularized by infamous cryptocurrency scammer Malone Lam, a 20 year old Miami resident who stole over $230M in Bitcoin on August 18, 2024.

Guy 1: *looking at Lam's crypto wallet* "That's probably 10 pretty pennies-"
Lam: "I'M GONNA LOSE A SHIT!"

Lose the farm

Referring to the historical forfeit or seizure of one's farm due to loss of income or inability to pay costs, this expression means one has lost a great deal of money gambling.

Megan: "Hey Joe! How'd the poker tournament go?

Joe: "I lost the farm."

Chris: Hey Sarah, I'm going to the racetrack to bet on horses.

Sarah: Don't lose the farm!

Take the risk or lose the chance

In the end, we only regret the chances we didn't take

''You should take the risk or lose the chance''

Losing On Yourself

To lose one's mind/marbles. Refers to when an individual forgets obvious things or makes easy mistakes, similarly to the symptoms of going senile.

As defined by Peter Smith.

'You're losing on yourself because you put your shoes in the fridge!'

Amy is losing on herself because she confused a person with a cat.

How lose?

When you are farming somebody in a video game it is proper manners to demand to know after every death how they "lost that." The most effective way of doing this is constantly asking them "HOW" in the chat until they succumb to a rage fueled meltdown.

*headshots marvin*
walter: marvin how did you lose that?
marvin: what are you talking about yo-
water: HOW LOSE?
marvin: I SAID I-
water: HOWWW???
*marvin ragequits*