When a man is having sex for the first time and is inexperienced so doesn't know how to use lube so is a Lube Noob.
Girl: Do you know how to use lube?
Boy: No I'm a lube noob
Metaphorical pain relieving ointment for middle-aged gamers. Specifically formulated to relieve the discomfort of being brutally killed (most commonly by a teenager) within seconds of deploying into FPS war zone.
Jake: Right, get ready boys, we’re going to kick some….
Raymond: Motherfucker, some arsehole just one-shotted me. I hadn’t even hit the ground
Carl: Thank god for the noob lube!
Raymond: It still stings the ring
Jake: Is that toxic?