It is when you are so tired, drunk, or drugged, that you brain no longer works or filter out thought. You say whatever you think. No one knows what you are talking about, because your thoughts have no focus.
"Dude, what are you talking about. You must have drunk brain. Go sleep it off."
A person who has consumed so much alcohol, that sometimes they act drunk without have had anything to drink.
To the astonishment of the police officers at the station, Dwayne passed the drink driving test… apparently he was a wet brain drunk.