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The Uno reverse card meme trend began around May 10, 2018 when a user linked Uno to the existing "No U" meme. It was a natural fit given that "No U" is an anagram of "Uno." From there, users on the Internet transformed the "No U" Uno card meme into the Uno reverse card meme and hilarity ensued.
Bill:U fat
Jack:*uses uno reverse card*
Bill:Oh no im fat now
A meme card is based on a card game called uno, Under the official Uno rules, when an Uno reverse card is played, the direction of play is reversed. If the play was going clockwise, it now goes counter-clockwise and vice versa and so it become meme which called "resist" or "no u"
Person 1: bro have you seen Joe?
Person 2: what's Joe? <--using Uno Reverse Card
Person 1: who's Joe* <still didn't realize he has made a giant no u mistake
Person 2: JOE MAMA (cannot resist by saying who Joe mama anymore)
Person 1:*think again of what he did in his life*
A very strong weapon no one can avoid.
Bully: Yo mom so stupid she took a spoon to the super bowl!!!
Me: *uno reverse card*
Bully: IU IUD O HIUOX o OUIG Tyi oce iuG guyi!!!!!!!
The ultimate comeback no one can reverse
Guy 1: Ur mommy in ma bed yo
Guy 2: No u
Guy 1: UNO REVERSE CARD
Me: Hey, look there's a zombie behind you!
Some random dude that's a complete bitch: No U
Me: Uno Reverse Card
Some random dude that's a complete bitch: Gets turned into a zombie then I kill him and the other zombie.